For Republicans, has the Senate Moved out of Reach?

The unexpected loss by moderate Republican Mike Castle in Delaware to the conservative newcomer Christine O'Donnell has just made it less likely that Republicans can retake the Senate in 2010.  Heading into November the GOP holds 41 seats and none appear to be at risk. The GOP is expected to pickup AR, ND, and IN as well as CO and PA for 5 new seats. Delaware was expected to be number 6 with the GOP reaching 57 seats and need only 4 more - IL, CA, NV, WA, and WI are all possibilities with CT and WV as long shots. The GOP would have needed 4 of those 7 a tall but possible order. Now, the GOP needs to win 5 of the 7. I can still happen, but it will tougher after tonight.